Skrein made his acting debut in Plan B's short film Michelle. Skrein got his first lead role in Plan B's Ill Manors. Skrein portrayed Daario Naharis in the third season of the television series Game of Thrones. However, in the fourth season of the series, he had been replaced by Dutch actor Michiel Huisman. Skrein states that "behind the scenes politics" had forced him to leave the show. In 2014, Skrein was cast in The Transporter: Refueled, replacing Jason Statham as the lead. Though the film was critically panned, his performance was praised. In 2016, Skrein played the lead villain, Ajax, in the blockbuster action film Deadpool.
On 23 October 2015 Skrein was cast in sci-fi thriller, Gateway 6, alongside Rhys Ifans, with Tanel Toom making his directorial debut. Filming will commence in Estonia in the spring of 2016. On 29 October 2015 Skrein was cast in psychological revenge thriller, In Darkness, alongside Natalie Dormer and Stacy Martin; principal photography will begin early 2016.
The fast-paced action movie is again set in the criminal underworld in France, where Frank Martin is known as The Transporter, because he is the best driver and mercenary money can buy. In this installment, he meets Anna and they attempt to take down a group of ruthless Russian human traffickers who also have kidnapped Frank’s father.
A blind musician hears a murder committed in the apartment upstairs from hers that sends her down a dark path into London's gritty criminal underworld.
A young girl with special abilities after escaping from an asylum enters back into the chaotic reality around her, making unexpected allies along the way.
London, modern day: Joe, a mild mannered young man is bored by his life. When his beloved brother is murdered Joe finds solace in Piggy, one of his brother's old friends. Piggy helps Joe to cope with grief, intent on saving him and helping him get justice for his brother's killing. As their friendship grows Joe finds himself in an increasing dangerous and murky world of violence and revenge. As Joe life collapses around him he starts to question who Piggy really is, and how honest he's really been with him. When Joe confronts Piggy a series of events are put in place that lead to a disastrous climax. Written by Anonymous (IMDb.com).