Skrein made his acting debut in Plan B's short film Michelle. Skrein got his first lead role in Plan B's Ill Manors. Skrein portrayed Daario Naharis in the third season of the television series Game of Thrones. However, in the fourth season of the series, he had been replaced by Dutch actor Michiel Huisman. Skrein states that "behind the scenes politics" had forced him to leave the show. In 2014, Skrein was cast in The Transporter: Refueled, replacing Jason Statham as the lead. Though the film was critically panned, his performance was praised. In 2016, Skrein played the lead villain, Ajax, in the blockbuster action film Deadpool.
On 23 October 2015 Skrein was cast in sci-fi thriller, Gateway 6, alongside Rhys Ifans, with Tanel Toom making his directorial debut. Filming will commence in Estonia in the spring of 2016. On 29 October 2015 Skrein was cast in psychological revenge thriller, In Darkness, alongside Natalie Dormer and Stacy Martin; principal photography will begin early 2016.
When a successful New York public defender loses his first case, he is pulled into a drug heist by a former client in an effort to beat the broken system at its own game.
Ensemble film revolving around characters living in Forest Gate, London. Over the course of a few days, six inter-linking stories explore issues of drug use, prostitution and urban poverty.
When emerging fashion model Emma gets a chance to pursue her dream of becoming an international top model, she leaves her everyday life in Denmark behind, and moves to Paris. At a photo shoot in her new hometown, she meets the attractive photographer Shane White and they fall in love. But their relationship soon turns into a dangerous obsession for Emma.
A coming-of-age story set in 1919 about 14 year old Faisal, an Arab prince who is dispatched from the deserts of Arabia to London by his warrior father, Prince Abd Al-Aziz, on a high stakes diplomatic mission to secure the formation of his country.